LYMPHOID NEOPLASIA A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma
نویسندگان
چکیده
1Department of Pediatrics, Hollings Cancer Center, Medical University of South Carolina, Charleston; 2Department of Pharmaceutical and Biomedical Sciences, Hollings Cancer Center, Medical University of South Carolina, Charleston; 3Divison of Biostatistics and Epidemiology, Hollings Cancer Center, Medical University of South Carolina, Charleston; 4Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston; 5Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD; 6Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA; and 7Department of Medicine, Hollings Cancer Center, Medical University of South Carolina, Charleston
منابع مشابه
A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma.
The serine/threonine Pim kinases are up-regulated in specific hematologic neoplasms, and play an important role in key signal transduction pathways, including those regulated by MYC, MYCN, FLT3-ITD, BCR-ABL, HOXA9, and EWS fusions. We demonstrate that SMI-4a, a novel benzylidene-thiazolidine-2, 4-dione small molecule inhibitor of the Pim kinases, kills a wide range of both myeloid and lymphoid ...
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New approaches are needed for the treatment of patients with T-cell acute lymphoblastic leukemia (T-ALL) who fail to achieve remission with chemotherapy. Analysis of the effects of pan-PIM protein kinase inhibitors on human T-ALL cell lines demonstrated that the sensitive cell lines expressed higher PIM1 protein kinase levels, whereas T-ALL cell lines with NOTCH mutations tended to have lower l...
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تاریخ انتشار 2010